Quantum information science (QIS) applies the best understanding of the sub-atomic world—quantum theory—to generate new knowledge and technologies. Through developments in QIS, the United States can improve its industrial base, create jobs, and provide economic and national security benefits. Prior examples of QIS-related technologies include semiconductor microelectronics, photonics, the global positioning system (GPS), and magnetic resonance imaging (MRI). These underpin significant parts of the national economic and defense infrastructure. Future scientific and technological discoveries from QIS may be even more impactful. Long-running U.S. Government investments in QIS and more recent industry involvement have transformed this scientific field into a nascent pillar of the American research and development enterprise. The Trump administration is committed to maintaining and expanding American leadership in QIS to enable future long-term benefits from, and protection of, the science and technology created through this research. Based on the collective input of all the Government agencies invested or interested in QIS, this document presents a national strategic approach to achieving this goal.