DOI
0.1007/s11024-008-9108-9
Directed Evolution: A Historical Exploration into an Evolutionary Experimental System of Nanobiotechnology, 1965-2006
论文题名译名
定向进化：纳米生物技术进化实验系统的历史探索，1965-2006
摘要
This study explores the history of nanotechnology from the perspectiveof protein engineering, which differs from the history of nanotechnology that hasarisen from mechanical and materials engineering; it also demonstrates points ofconvergence between the two. Focusing on directed evolution—an experimentalsystem of molecular biomimetics that mimics nature as an inspiration for materialdesign—this study follows the emergence of an evolutionary experimental systemfrom the 1960s to the present, by detailing the material culture, practices, andtechniques involved. Directed evolution, as an aspect of nanobiotechnology, is alsodistinct from the dominant biotechnologies of the 20th century. The experimentalsystems of directed evolution produce new ways of thinking about moleculardiversity that could affect concepts concerning both biology and life.
中文摘要
本研究从蛋白质工程的角度探讨了纳米技术的历史，蛋白质工程不同于机械和材料工程产生的纳米技术历史；它还展示了两者之间的契合点。本研究关注定向进化——一种模仿自然的分子仿生实验系统，以此作为材料设计的灵感来源。本研究遵循了20世纪60年代至今进化实验系统的出现，详细介绍了所涉及的材料文化、实践和技术。定向进化作为纳米生物技术的一个方面，也不同于20世纪占主导地位的生物技术。定向进化的实验系统产生了对分子多样性的新思考方式，这可能会影响生物学和生命的概念。
来源关键词
Directed evolution
;
RNA world
;
Scanning probe microscopy
;
Molecular biomimetics
;
Nanotechnology
;
Molecular diversity
来源智库
Consortium for Science, Policy, and Outcomes (United States)
NSTL唯一标识符
JA202305300000059ZX
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